Trends in Endocrinology & Metabolism
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New articles

Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

August 20, 2022

Science & Society

Come out and play

  • Marco Pagliusi Jr
First published:August 20, 2022
We all know that we should exercise so that we can reach a healthier physiological state. However, this knowledge is often not enough to prompt us to regularly engage in exercise. Here, I discuss why and what we could do to try to overcome this circumstance.

Understanding lactate sensing and signalling

  • Michelangelo Certo,
  • Alba Llibre,
  • Wheeseong Lee,
  • Claudio Mauro
First published:August 20, 2022
Metabolites generated from cellular and tissue metabolism have been rediscovered in recent years as signalling molecules. They may act as cofactor of enzymes or be linked to proteins as post-translational modifiers. They also act as ligands for specific receptors, highlighting that their neglected functions have, in fact, a long standing in evolution. Lactate is one such metabolite that has been considered for long time a waste product of metabolism devoid of any biological function. However, in the past 10 years, lactate has gained much attention in several physio-pathological processes.

August 19, 2022


Fructose 1-phosphate, an evolutionary signaling molecule of abundancy

  • Martijn C.G.J. Brouwers
First published:August 19, 2022
Evidence is accumulating that specifically fructose exerts adverse cardiometabolic effects in humans. Recent experimental studies have shown that fructose not only serves as a substrate for, among others, intrahepatic lipid formation, but also has a signaling function. It is postulated that fructose 1-phosphate (F1-P) has evolved as a signaling molecule of abundancy that stimulates nutrient absorption, lipid storage, and reproduction. Such a role would provide an explanation for why fructose contributes to the pathogenesis of evolutionary mismatch diseases, including nonalcoholic fatty liver disease (NAFLD), cardiovascular disease, polycystic ovary syndrome (PCOS), and colorectal cancer, in the current era of nutritional abundance.

August 9, 2022

Feature Review

Immune–metabolic interactions in homeostasis and the progression to NASH

  • Joanne A. Hoogerland,
  • Bart Staels,
  • David Dombrowicz
First published:August 09, 2022
The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) and predisposes to fibrosis and hepatocellular carcinoma (HCC). The importance of the immune system in hepatic physiology and in the progression of NAFLD is increasingly recognized. At homeostasis, the liver participates in immune defense against pathogens and in tolerance of gut-derived microbial compounds.

August 8, 2022


Location matters: hexokinase 1 in glucose metabolism and inflammation

  • Sivaraj M. Sundaram,
  • Luke A. Doughty,
  • Michael W. Sereda
First published:August 08, 2022
Hexokinase (HK)-1 mitochondrial-binding mechanisms and consequential physiological relevance remain unclear. Recently, De Jesus et al. studied myeloid cells with HK1 carrying mutated mitochondrial-binding domains (MBDs) and provided evidence that HK1 localization controls glucose metabolic fate. Increases in cytosolic HK1 may also contribute to the inflammation associated with diabetes and aging.

August 6, 2022


OPA1 regulation of mitochondrial dynamics in skeletal and cardiac muscle

  • John Noone,
  • Donal J. O’Gorman,
  • Helena C. Kenny
First published:August 06, 2022
The mitochondria are double-membrane organelles integral for energy metabolism. Mitochondrial dynamics is regulated by inner and outer mitochondrial membrane (IMM and OMM) proteins, which promote fission and fusion. Optic atrophy 1 (OPA1) regulates IMM fusion, prevents apoptosis, and is a key regulator of morphological change in skeletal and cardiac muscle physiology and pathophysiology. OPA1 fuses the inner membranes of adjacent mitochondria, allowing for an increase in oxidative phosphorylation (OXPHOS).

August 4, 2022


Energy as the cornerstone of environmentally driven sex allocation

  • Benjamin Geffroy
First published:August 04, 2022
In recent years, observations of distinct organisms have linked the quality of the environment experienced by a given individual and the sex it will develop. In most described cases, facing relatively harsh conditions resulted in masculinization, while thriving in favorable conditions promoted the development of an ovary. This was shown indistinctively in some species presenting a genetic sex determination (GSD), which were able to sex-reverse, and in species with an environmental sex determination (ESD) system.

February 9, 2022


Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson’s disease

(Trends in Endocrinology & Metabolism 33, 147–157; 2022)

  • Ehraz Anis,
  • Aoji Xie,
  • Lena Brundin,
  • Patrik Brundin
First published:February 09, 2022
Due to an error during the proofreading process, Figures 2 and 3 were switched in the manuscript, and as a result, the captions and citations in text referring to the figures do not match up. We apologize for any inconvenience caused to readers.